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Most Requested Journal Articles 2Q05-Chemistry and Related

Following is one of the journal articles most requested by researchers using CAS online services.

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CAS indexed 64 chemical substances from this document. CAS subject entries for this document include: Coupling reaction; Wittig reaction; Lactonization; and 3 additional concepts.

CAPLUS COPYRIGHT 2005 ACS on STN

TITLE:	Total Syntheses of Epothilones B and D
AUTHOR(S):	Jung, Jae-Chul; Kache, Rajashaker; Vines, Kimberly K.; Zheng, Yan-Song; Bijoy, Panicker; Valluri, Muralikrishna; Avery, Mitchell A.
CORPORATE SOURCE:	Department of Medicinal Chemistry, School of Pharmacy, Department of Chemistry and National Center for Natural Products Research, University of Mississippi, University, MS, 38677-1848, USA
SOURCE:	Journal of Organic Chemistry (2004), 69(26), 9269-9284 CODEN: JOCEAH; ISSN: 0022-3263
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
A convergent, total synthesis of epothilones B (I; X = O) and D (I; X = bond) is described. The key steps are Normant coupling to establish the desired (Z)-stereochem. at C12-C13, Wadsworth-Emmons olefination, diastereoselective aldol condensation of aldehyde II with the enolate of keto acid derivs. to form the C6-C7 bond, selective deprotection, and macrolactonization.

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