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Most Requested Journal Articles 2Q05-Chemistry and Related

Following is one of the journal articles most requested by researchers using CAS online services.

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CAS indexed 82 chemical substances from this document. CAS subject entries for this document include: Peptide library; Peptides, preparation.

CAPLUS COPYRIGHT 2005 ACS on STN

TITLE:	A useful bicyclic topological decapeptide template for solution-phase combinatorial synthesis of tetrapodal libraries
AUTHOR(S):	Xu, Q.; Borremans, F.; Devreese, B.
CORPORATE SOURCE:	Department of Organic Chemistry, University of Ghent, Ghent, 9000, Belg.
SOURCE:	Tetrahedron Letters (2001), 42(41), 7261-7263 CODEN: TELEAY; ISSN: 0040-4039
PUBLISHER:	Elsevier Science Ltd.
LANGUAGE:	English

ABSTRACT:
An orthogonally protected bicyclic decapeptide has been constructed and evaluated as a template for combinatorial synthesis. This peptide, bicyclo(KCKPGKCKPG), has four (quasi) orthogonal protecting groups (Fmoc, Boc, Aloc and Dde), allowing site-selective assembly of building blocks. This template is found most useful for soln.-phase combinatorial synthesis of tetrapodal libraries. Four groups of three different amino acids yielded all theor. expected 27x3 library compds.