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Most Requested Journal Articles 2Q04-Chemistry and Related

Following is one of the journal articles most requested by researchers using CAS online services.

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CAS indexed 136 chemical substances from this document. CAS subject entries for this document include: Sulfonic acids, reactions; Amination; Amination catalysts; and 2 additional concepts.

CAPLUS COPYRIGHT 2004 ACS on STN

TITLE:	Expanding Pd-Catalyzed C-N Bond-Forming Processes: The First Amidation of Aryl Sulfonates, Aqueous Amination, and Complementarity with Cu-Catalyzed Reactions
AUTHOR(S):	Huang, Xiaohua; Anderson, Kevin W.; Zim, Danilo; Jiang, Lei; Klapars, Artis; Buchwald, Stephen L.
CORPORATE SOURCE:	Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
SOURCE:	Journal of the American Chemical Society (2003), 125(22), 6653-6655 CODEN: JACSAT; ISSN: 0002-7863
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
The first general method for the Pd-catalyzed amination of aryl tosylates and benzenesulfonates was developed utilizing ligand 2,4,6-(Me2CH)3C6H2C6H4PCy2-2, which belongs to a new generation of biaryl monophosphine ligands. In addn., the new catalyst system enables amidation of aryl arenesulfonates and aq. amination protocols that do not necessitate the use of cosolvents. The substrate scope has been significantly expanded to include aryl halides contg. primary amides and free carboxylic acid groups. In the case of multifunctional substrates, the Pd-catalyzed amination can provide selectivity that is complementary to the Cu-catalyzed C-N bond-forming processes.

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