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Most Requested Journal Articles 2Q04-Chemistry and Related

Following is one of the journal articles most requested by researchers using CAS online services.

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CAS indexed 58 chemical substances from this document. CAS subject entries for this document include: Acids, reactions; Group IIIA element compounds; Crystal structure; and 4 additional concepts.

CAPLUS COPYRIGHT 2004 ACS on STN

TITLE:	A rationally designed universal catalyst for Suzuki-Miyaura coupling processes
AUTHOR(S):	Walker, Shawn D.; Barder, Timothy E.; Martinelli, Joseph R.; Buchwald, Stephen L.
CORPORATE SOURCE:	Department of chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
SOURCE:	Angewandte Chemie, International Edition (2004), 43(14), 1871-1876 CODEN: ACIEF5; ISSN: 1433-7851
PUBLISHER:	Wiley-VCH Verlag GmbH & Co. KGaA
LANGUAGE:	English

ABSTRACT:
Scope, reactivity, and stability of a catalyst system, contg. a palladium catalyst and phosphine ligand I, in the Suzuki-Miyaura coupling reaction, is reported. Sterically hindered biaryls, e.g., II, were prepd., in high yields, by coupling of arylboronic acids with aryl bromides and chlorides. Furthermore, coupling of aryl chlorides with n-hexyl-9-BBN or alkylboronic acids afforded the corresponding alkylarenes in excellent yields.