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Most Requested Journal Articles 2Q04-Chemistry and Related

Following is one of the journal articles most requested by researchers using CAS online services.

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CAS indexed 44 chemical substances from this document. CAS subject entries for this document include: Metathesis; Asymmetric synthesis and induction; Macrocyclization.

CAPLUS COPYRIGHT 2004 ACS on STN

TITLE:	A Convergent Synthesis of the Macrocyclic Core of Cytotrienins: Application of RCM for Macrocyclization
AUTHOR(S):	Evano, Gwilherm; Schaus, Jennifer V.; Panek, James S.
CORPORATE SOURCE:	Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, Boston, MA, 02215, USA
SOURCE:	Organic Letters (2004), 6(4), 525-528 CODEN: ORLEF7; ISSN: 1523-7060
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
The asym. synthesis of the fully elaborated macrocyclic core (I) of cytotrienins A-D, potent apoptosis-inducing agents, is described. Synthetic highlights include the construction of the aniline bond using a copper-mediated amidation and the use of a ring-closing metathesis (RCM) reaction to efficiently install the (E,E,E)-triene and simultaneously construct the macrocyclic lactam.

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