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Home   •   Spotlight  •  rlist2002  •  Most Requested Journal Articles 2002-Chemistry and Related (4)

Most Requested Journal Articles 2002-Chemistry and Related

Following is one of the documents most requested by researchers using CAS electronic products.

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CAS indexed 111 chemical substances from this document. CAS subject entries for this document include: Amidation; Amidation catalysts; Arylation; and 2 additional concepts.

CAPLUS COPYRIGHT 2003 ACS

TITLE:	A general and efficient copper catalyst for the amidation of aryl halides and the N-arylation of nitrogen heterocycles
AUTHOR(S):	Klapars, Artis; Antilla, Jon C.; Huang, Xiaohua; Buchwald, Stephen L.
CORPORATE SOURCE:	Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
SOURCE:	Journal of the American Chemical Society (2001), 123(31), 7727-7729 CODEN: JACSAT; ISSN: 0002-7863
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
The authors have developed an extremely general, exptl. simple, and inexpensive catalyst system for the amidation of aryl halides and the N-arylation of heterocycles. Thus, reacting 4-RC6H4Cl (R = Me, MeO, MeO2C) with R1NHCOR2 [R1 = H, R2 = Ph; R1R2 = (CH2)3] to give 4-RC6H4NR1COR2 in 51 to 95% yield.

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