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Home   •   Spotlight  •  rlist2002  •  Most Requested Journal Articles 2002-Chemistry and Related (10)

Most Requested Journal Articles 2002-Chemistry and Related

Following is one of the documents most requested by researchers using CAS electronic products.

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CAS subject entries for this document include: Alkaloids, uses; Solid phase synthesis; Peptide coupling; and 4 additional concepts.

CAPLUS COPYRIGHT 2003 ACS

TITLE:	From .alpha.-amino acids to peptides: all you need for the journey
AUTHOR(S):	Najera, Carmen
CORPORATE SOURCE:	Departamento de Quimica Organica, Facultad de Ciencias, Universidad de Alicante, Alicante, 03080, Spain
SOURCE:	Synlett (2002), (9), 1388-1403 CODEN: SYNLES; ISSN: 0936-5214
PUBLISHER:	Georg Thieme Verlag
LANGUAGE:	English

ABSTRACT:
A review. Several tools necessary for the synthesis of peptides from .alpha.-amino acids are considered here. Different strategies for the asym. synthesis of .alpha.-amino acids are described. New chiral glycine and alanine imines as acyclic and cyclic templates for the asym. synthesis of different types of mono as well as dialkylated .alpha.-amino acids with acyclic and heterocyclic structures are reviewed. New polymer-supported cinchonidine and cinchonine ammonium salts and chiral binaphthol-derived aminoalkoxides (BINOLAMs), have been developed as catalysts for the asym. PTC alkylation of imino esters. For the protection of .alpha.-amino acids, new efficient reagents, Fmoc-P-OSu and Cbz-P-OSu [P-HOSu = poly(styrene-co-N-hydroxymaleimide)], have been developed.

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