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CAPLUS COPYRIGHT 2007 ACS on STN
| TITLE:
| Preparation of amino acid prodrugs |
| INVENTOR(S):
| Chandran, V. Ravi |
| PATENT ASSIGNEE(S):
| Signature Pharmaceuticals, LLC, USA |
| SOURCE:
| PCT Int. Appl., 292 pp. CODEN: PIXXD2 |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
WO 2005046575 A2 20050526 WO 2004-US24901 20040729
W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH,
CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD,
GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC,
LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI,
NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY,
TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
RW: BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW, AM,
AZ, BY, KG, KZ, MD, RU, TJ, TM, AT, BE, BG, CH, CY, CZ, DE, DK,
EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE,
SI, SK, TR, BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE,
SN, TD, TG
AU 2004289174 A2 20050526 AU 2004-289174 20040729
AU 2004289174 A1 20050526
CA 2534342 A1 20050526 CA 2004-2534342 20040729
EP 1660017 A2 20060531 EP 2004-816791 20040729
R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT,
IE, SI, LT, LV, FI, RO, MK, CY, AL, TR, BG, CZ, EE, HU, PL, SK, HR
JP 2007510621 T 20070426 JP 2006-522125 20040729
US 2006241017 A1 20061026 US 2006-343557 20060130
US 2006287244 A1 20061221 US 2006-442027 20060526
ABSTRACT:
The invention is directed to prodrugs having enhanced therapeutic properties and which are comprised of an amino acid bonded to a medicament or drug having a hydroxy, amino, carboxy or acylating deriv. Thus, the L-serine, L-threonine, and L-hydroxyproline esters of (.+-.)-ibuprofen were synthesized and assayed for antinociceptive potential. (.+-.)-Ibuprofen L-hydroxyproline ester was found to be more effective in antagonizing the acetylcholine-induced writhe when compared to other formulations and racemic or (S)-(+)-ibuprofen.
Updated 5/15/2007 1:30:55 PM
