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CAS indexed 70 chemical substances from this document.
CAS subject entries for this document include: Arylation; Arylation catalysts; Coupling reaction; and 10 additional concepts. | |
CAPLUS COPYRIGHT 2007 ACS on STN
| TITLE:
| Clickphosphines for transition metal-catalyzed reactions |
| INVENTOR(S):
| Zhang, Xumu |
| PATENT ASSIGNEE(S):
| The Penn State Research Foundation, USA |
| SOURCE:
| PCT Int. Appl., 47pp. CODEN: PIXXD2 |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
WO 2006130842 A1 20061207 WO 2006-US21518 20060602
W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH,
CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD,
GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR,
KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX,
MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE,
SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC,
VN, YU, ZA, ZM, ZW
RW: AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE,
IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR, BF, BJ,
CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG, BW, GH,
GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW, AM, AZ, BY,
KG, KZ, MD, RU, TJ, TM
US 2007088166 A1 20070419 US 2006-445464 20060602
ABSTRACT:
Phosphine triazole ligand compds., I and II (clickphosphines; X = H, (un)substituted alkyl, (un)substituted cycloalkyl, (un)substituted aryl, ferrocenyl, organosilyl, etc.; Y = H, (un)substituted alkyl, (un)substituted aryl, (un)substituted cycloalkyl, ferrocenyl, organosilyl, halo, etc.; R = (un)substituted alkyl, (un)substituted cycloalkyl, (un)substituted aryl, etc.), prepd. through click chem., complex with transition metals to form transition metal-phosphine triazole ligand complexes. Thus, Grignard reaction of EtMgBr with phenylacetylene in THF followed by treatment with Ph azide gave 75% 1,5-diphenyltriazole which on lithiation with LDA followed by phosphination with t-Bu2PCl gave title clickphosphine, 4-di-tert-butylphosphino-1,5-diphenyl-1H-[1,2,3]triazole. These complexes are useful catalysts in coupling reactions such as Suzuki-Miyaura coupling, Stille coupling, Negishi coupling, Sonogashira coupling, carbon-heteroatom bond-forming reactions (C-O and C-N), alpha alkylation of carbonyls, Heck coupling reactions, and hydrogenation reactions.
Updated 5/15/2007 1:31:48 PM
