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Most Requested Journal Articles 1Q07-Chemistry and Related Science

Following is one of the journal articles most requested by researchers using CAS electronic products.

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CAS indexed 73 chemical substances from this document. CAS subject entries for this document include: Ketones, preparation; Aryl bromides; Iodides, reactions; and 4 additional concepts.

CAPLUS COPYRIGHT 2007 ACS on STN

TITLE:	Highly Selective Room-Temperature Copper-Catalyzed C-N Coupling Reactions
AUTHOR(S):	Shafir, Alexandr; Buchwald, Stephen L.
CORPORATE SOURCE:	Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
SOURCE:	Journal of the American Chemical Society (2006), 128(27), 8742-8743 CODEN: JACSAT; ISSN: 0002-7863
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
Through the use of cyclic .beta.-diketones as supporting ligands, the copper-catalyzed coupling of aryl iodides with aliph. amines occurs at room temp. in as little as 1 h. These high reaction rates allow for the coupling of a wide range of aryl and heteroaryl iodides at room temp. This method is highly tolerant of a no. of reactive functional groups, including -Br and arom. -NH2 as well as phenolic and aliph. -OH. The high selectivity of the CuI-.beta.-diketone catalyst for aliph. amines represents a useful complement to the palladium-based methods.