Following is one of the patent documents most requested by researchers using CAS electronic products.
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CAS indexed 117 chemical substances from this document.
CAS subject entries for this document include: Electrophiles; Organic synthesis; Grignard reagents. | |
CAPLUS COPYRIGHT 2006 ACS on STN
| TITLE:
| Method of preparing organomagnesium compounds |
| INVENTOR(S):
| Knochel, Paul; Krasovskiy, Arkady |
| PATENT ASSIGNEE(S):
| Ludwig-Maximilians-Universitaet Muenchen, Germany |
| SOURCE:
| Eur. Pat. Appl., 22 pp. CODEN: EPXXDW |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
EP 1582523 A1 20051005 EP 2004-8081 20040402
R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT,
IE, SI, LT, LV, FI, RO, MK, CY, AL, TR, BG, CZ, EE, HU, PL, SK, HR
EP 1582524 A1 20051005 EP 2005-7179 20050401
R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT,
IE, SI, LT, LV, FI, RO, MK, CY, AL, TR, BG, CZ, EE, HU, PL, SK,
BA, HR, IS, YU
US 2005218532 A1 20051006 US 2005-97707 20050401
JP 2005290001 A2 20051020 JP 2005-106858 20050401
ABSTRACT:
The present invention is directed to a reagent for use in the prepn. of organomagnesium compds., R1(MgX)n.bul.LiY (n = 1, 2; R1 = (un)substituted C4-24 aryl or C3-24 heteroaryl contg. one or more heteroatoms such as B, O, N, S, Se, P, linear or branched (un)substituted C1-20 alkyl, C1-20 alkenyl, C1-20 alkynyl, C3-20 (un)substituted cycloalkyl, etc.; X, Y = Cl, Br, I, etc.), as well as to a method of prepg. such organomagnesium compds. The present invention furthermore provides a method of prepg. functionalized or unfunctionalized org. compds. as well as the use of the reagents of the present invention in the prepn. of organometallic compds. and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts - LiY in the prepn. of organometallic compds. and their reactions with electrophiles and to an organometallic compd. which is obtainable by the disclosed method. Thus, Grignard reaction of i-PrCl with Mg in the presence of LiCl in THF gave i-PrMgCl.bul.LiCl which on sequential treatment with 4-BrC6H4CN in THF at -7.degree. and PhCHO at -7.degree. gave 81% 4-NCC6H4CH(OH)Ph.
Updated 5/4/2007 9:08:10 AM
