• CAS Science Spotlight Home
• Most Requested Journal Articles 1Q06-Chemistry and Related
• About
• What's New

Home   •   Spotlight  •  rlist1q06j  •  Most Requested Journal Articles 1Q06-Chemistry and Related (8)

Most Requested Journal Articles 1Q06-Chemistry and Related

Following is one of the journal articles most requested by researchers using CAS electronic products.

---

Cycloaddition reaction; Cycloaddition reaction catalysts; Coupling reaction catalysts; and 4 additional concepts.

CAPLUS COPYRIGHT 2006 ACS on STN

TITLE:	Cu(I)-catalyzed alkyne-azide click cycloadditions from a mechanistic and synthetic perspective
AUTHOR(S):	Bock, Victoria D.; Hiemstra, Henk; van Maarseveen, Jan H.
CORPORATE SOURCE:	Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, 1018 WS, Neth.
SOURCE:	European Journal of Organic Chemistry (2005), Volume Date 2006, (1), 51-68 CODEN: EJOCFK; ISSN: 1434-193X
PUBLISHER:	Wiley-VCH Verlag GmbH & Co. KGaA
LANGUAGE:	English

ABSTRACT:
A review. Cu(I)-catalyzed alkyne-azide cycloaddn. provides 1,4-disubstituted 1,2,3-triazoles with such efficiency and scope that the transformation was described as "click" chem. An overview of the mechanism of this remarkable reaction is presented as a means to explain the myriad of exptl. results, particularly the various methods of catalyst generation, solvent and substrate effects, and choice of base or ligand. Both soln.-phase and solid-phase results are comprehensively examd.