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Most Requested Journal Articles 1Q05-Chemistry and Related

Following is one of the journal articles most requested by researchers using CAS online services.

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CAS indexed 67 chemical substances from this document. CAS subject entries for this document include: Ketones, reactions; Amino acids, preparation; Alkenes, reactions; and 8 additional concepts.

CAPLUS COPYRIGHT 2005 ACS on STN

TITLE:	Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions
AUTHOR(S):	Cobb, Alexander J. A.; Shaw, David M.; Longbottom, Deborah A.; Gold, Johan B.; Ley, Steven V.
CORPORATE SOURCE:	Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK
SOURCE:	Organic & Biomolecular Chemistry (2005), 3(1), 84-96 CODEN: OBCRAK; ISSN: 1477-0520
PUBLISHER:	Royal Society of Chemistry
LANGUAGE:	English

ABSTRACT:
Tetrazole and acylsulfonamide organo catalysts derived from proline have been synthesized and applied to the asym. Mannich, nitro-Michael and aldol reactions to give results that are superior to the proline-catalyzed counterpart. The prepn. of 5-(2S)-2-pyrrolidinyl-1H-tetrazole (I) and its enantiomer were reported. The stereoselective Mannich reaction of 3-pentanone with [(4-methoxyphenyl)imino]acetic acid Et ester gave (.alpha.S,1S)-.alpha.-[(4-methoxyphenyl)amino]-2-(oxo)cyclohexaneacetic acid Et ester (II).

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