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CAS indexed 1438 chemical substances from this document.
CAS subject entries for this document include: Nervous system, disease; Nerve, disease; Immunity; and 8 additional concepts. | |
CAPLUS COPYRIGHT 2004 ACS on STN
| TITLE:
| Preparation of pyrazole derivatives as JNK inhibitors |
| INVENTOR(S):
| Ohi, Norihito; Sato, Nobuaki; Soejima, Motohiro; Doko, Takashi; Terauchi, Taro; Naoe, Yoshimitsu; Motoki, Takafumi |
| PATENT ASSIGNEE(S):
| Eisai Co., Ltd., Japan |
| SOURCE:
| PCT Int. Appl., 561 pp. CODEN: PIXXD2 |
| LANGUAGE:
| Japanese |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- --------------- --------
WO 2003101968 A1 20031211 WO 2003-JP6777 20030529
W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN,
CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH,
GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR,
LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM,
PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT,
TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW, AM, AZ, BY, KG, KZ,
MD, RU, TJ, TM
RW: GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW, AT, BE, BG,
CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC,
NL, PT, RO, SE, SI, SK, TR, BF, BJ, CF, CG, CI, CM, GA, GN, GQ,
GW, ML, MR, NE, SN, TD, TG
ABSTRACT:
The title compds. I [R1 represents (CO)h(NRa)j(CRb:CRc)kAr (wherein Ra, Rb, and Rc each independently represents hydrogen, halogeno, hydroxy, optionally substituted C1-6 alkyl, etc.); Ar = (un)substituted arom. heterocyclic ring, etc.; h, j, k = 0 or 1; Cy is a 5- or 6-membered arom. heterocycle; and V represents L-X-Y (wherein L is a single bond, optionally substituted C1-6 alkylene, etc.; X is a single bond, O, CO, etc.; and Y is hydrogen, halogeno, nitro, etc.); n = 0 - 4] are prepd. Compds. of this invention in vitro showed IC50 values of 63 nM to 578 nM against JNK-3.
Updated 5/4/2007 7:54:10 AM
