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CAS indexed 330 chemical substances from this document.
CAS subject entries for this document include: Monoglycerides; Drug delivery systems; Quaternary ammonium compounds, biological studies; and 78 additional concepts. | |
CAPLUS COPYRIGHT 2004 ACS on STN
| TITLE:
| Pharmaceutical compositions and methods for improved delivery of hydrophobic therapeutic agents |
| INVENTOR(S):
| Patel, Manesh V.; Chen, Feng-Jing |
| PATENT ASSIGNEE(S):
| Lipocine, Inc., USA |
| SOURCE:
| PCT Int. Appl., 98 pp. CODEN: PIXXD2 |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- --------------- --------
WO 2000050007 A1 20000831 WO 2000-US165 20000105
W: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU,
CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL,
IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA,
MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI,
SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW, AM, AZ,
BY, KG, KZ, MD, RU, TJ, TM
RW: GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW, AT, BE, CH, CY, DE,
DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, BF, BJ, CF,
CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG
US 6294192 B1 20010925 US 1999-258654 19990226
AU 2000022242 A5 20000914 AU 2000-22242 20000105
NZ 513810 A 20010928 NZ 2000-513810 20000105
EP 1158959 A1 20011205 EP 2000-901394 20000105
R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT,
IE, SI, LT, LV, FI, RO
JP 2002537317 T2 20021105 JP 2000-600619 20000105
ABSTRACT:
The present invention relates to triglyceride-free pharmaceutical compns. for delivery of hydrophobic therapeutic agents. Compns. of the present invention include a hydrophobic therapeutic agent and a carrier, where the carrier is formed from a combination of a hydrophilic surfactant and a hydrophobic surfactant. Upon diln. with an aq. solvent, the compn. forms a clear, aq. dispersion of the surfactants contg. the therapeutic agent. The invention also provides methods of treatment with hydrophobic therapeutic agents using these compns. A pharmaceutical compn. contained cyclosporin 0.14, Cremophor RH-40 0.41, Arlacel186 0.29, sodium taurocholate 0.26, and propylene glycol 0.46 mg.
Updated 5/4/2007 7:44:01 AM
