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Most Cited Patent Families 1999-Chemistry and Related

Following is a CAS database record representing a highly cited patent family.

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CAS indexed 468 chemical substances from this document. CAS subject entries for this document include: Anticoagulants and Antithrombotics.

CAPLUS COPYRIGHT 2001 ACS

TITLE:	Heterocyclic and aromatic amidine derivatives and salts thereof
INVENTOR(S):	Nagahara, Takayasu; Kanaya, Naoaki; Inamura, Kazue; Yokoyama, Yukio
PATENT ASSIGNEE(S):	Daiichi Pharmaceutical Co., Ltd., Japan
SOURCE:	Eur. Pat. Appl., 94 pp. CODEN: EPXXDW
LANGUAGE:	English

PATENT INFORMATION:

PATENT NO.       KIND  DATE           APPLICATION NO.  DATE
---------------  ----  --------       ---------------  --------
EP 540051         A1   19930505       EP 1992-118705   19921030
EP 540051         B1   19960403
    R:  AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LI, LU, NL, PT, SE
ZA 9208276        A    19930506       ZA 1992-8276     19921026
IL 103564         A1   19981206       IL 1992-103564   19921027
NO 9204164        A    19930503       NO 1992-4164     19921029
DE 4236574        A1   19930506       DE 1992-4236574  19921029
CA 2081836        AA   19930501       CA 1992-2081836  19921030
AU 9227470        A1   19930506       AU 1992-27470    19921030
AU 666137         B2   19960201
JP 05208946       A2   19930820       JP 1992-292892   19921030
JP 2879718        B2   19990405
US 5300851        A    19940405       US 1992-969369   19921030
HU 65890          A2   19940728       HU 1992-3433     19921030
AT 136293         E    19960415       AT 1992-118705   19921030
ES 2088073        T3   19960801       ES 1992-118705   19921030
PL 170312         B1   19961129       PL 1992-296439   19921030
JP 10291931       A2   19981104       JP 1998-85454    19921030
CZ 284381         B6   19981111       CZ 1992-3276     19921030
SK 279807         B6   19990413       SK 1992-3276     19921030
RU 2139851        C1   19991020       RU 1992-4542     19921030
CN 1072677        A    19930602       CN 1992-114304   19921031
CN 1049434        B    20000216
US 5576343        A    19961119       US 1995-468304   19950606
US 5620991        A    19970415       US 1995-471173   19950606
CN 1168885        A    19971231       CN 1997-110745   19970416
CN 1168886        A    19971231       CN 1997-110748   19970416
CN 1062865        B    20010307
US 5866577        A    19990202       US 1997-924504   19970905
US 5962695        A    19991005       US 1998-131235   19980807

ABSTRACT:
The title compds. I (where the benzeno-Z ring is indolyl, benzimidazolyl, naphthyl, etc.; R = HN:CNH2; R1 = H, alkoxy; R2 = H, alkyl, alkoxy, etc.; R3 = H, carboxyl, etc.; R4 = H, OH, alkyl, alkoxy; A = C1-4 alkylene; X = single bond, O, S, CO; n = 0-4; Y = heterocyclic or cyclic hydrocarbon moiety) useful as anticoagulant agents were prepd. by treating I (R = CN) with R5OH (R5 = alkyl) to give I (R = R5OC:NH) followed by treatment with NH3. Some of the prepd. compds. showed strong anticoagulant activity through their specific anti-FXa activity in comparison with DABE.

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