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Home   •   Spotlight  •  pcite99  •  Most Cited Patent Families 1999-Chemistry and Related (3)

Most Cited Patent Families 1999-Chemistry and Related

Following is a CAS database record representing a highly cited patent family.

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CAS indexed 12 chemical substances from this document. CAS subject entries for this document include: Sweetening agents.

CAPLUS COPYRIGHT 2001 ACS

TITLE:	New dipeptide derivatives and analogs useful as sweetening agents, and process for their preparation
INVENTOR(S):	Nofre, Claude; Tinti, Jean Marie
PATENT ASSIGNEE(S):
SOURCE:	Fr. Demande, 23 pp. CODEN: FRXXBL
LANGUAGE:	French

PATENT INFORMATION:

PATENT NO.       KIND  DATE           APPLICATION NO.  DATE
---------------  ----  --------       ---------------  --------
FR 2697844        A1   19940513       FR 1992-13615    19921112
FR 2697844        B1   19950127
US 5480668        A    19960102       US 1993-149365   19931109
CA 2139233        AA   19940526       CA 1993-2139233  19931110
WO 9411391        A1   19940526       WO 1993-FR1103   19931110
    W:  AU, BB, BG, BR, BY, CA, CZ, FI, HU, JP, KP, KR, KZ, LK, LV, MG,
	MN, MW, NO, NZ, PL, RO, RU, SD, SK, UA, UZ, VN
    RW: AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE,
	BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG
AU 9454681        A1   19940608       AU 1994-54681    19931110
AU 664663         B2   19951123
LT 3142           B    19950131       LT 1993-1457     19931110
EP 669935         A1   19950906       EP 1994-900182   19931110
EP 669935         B1   19960605
    R:  AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE
HU 72192          A2   19960328       HU 1994-3842     19931110
HU 218158         B    20000628
JP 08503206       T2   19960409       JP 1993-511787   19931110
AT 138935         E    19960615       AT 1994-900182   19931110
ES 2091114        T3   19961016       ES 1994-900182   19931110
RO 112621         B1   19971128       RO 1994-2023     19931110
RU 2107071        C1   19980320       RU 1994-46457    19931110
IL 107551         A1   19980816       IL 1993-107551   19931110
CZ 285018         B6   19990512       CZ 1994-3319     19931110
SK 280180         B6   19990910       SK 1994-1586     19931110
PL 177090         B1   19990930       PL 1993-306841   19931110
ZA 9308430        A    19940613       ZA 1993-8430     19931111
CN 1090571        A    19940810       CN 1993-114462   19931112
CN 1038747        B    19980617
FI 9405451        A    19941222       FI 1994-5451     19941121
NO 9405090        A    19941230       NO 1994-5090     19941230

ABSTRACT:
Title compds. I [R = C4-13 (un)satd. (a)cyclic hydrocarbyl; n = 1 or 2; Y = CO2Me, CO2Et, Me, CH2OH, CONMe2, Ph, 2-furyl, H; Z = CH2Ph, Ph, Bu, CO2Me, CO2Et, CO2Pr, fenchyloxycarbonyl, CONHR'; R' = Me, Et, Pr, isoamyl, CHMeCO2Me, dicyclopropylmethyl, 2,2,4,4-tetramethyl-3-thietanyl, etc.] are claimed, and are useful as sweeteners. I include aspartame (II) derivs., and show both higher sweetening power and increased stability vs. II. For example, reductive alkylation of aspartame by com. Me3CCH2CHO and NaBH3CN in MeOH at room temp. gave 62% title compd. III. Tested as aq. solns., the sweetening power of III was approx. 80-fold that of II. Also, in aq. soln. at pH 3 and 70.degree., the half-life of III was 55 h, vs. 24 h for II. Sweetening and/or stability data for some of the other claimed I are also reported.