Following is a CAS database record representing a highly cited patent family.
|
CAS indexed 1 chemical substance from this document.
CAS subject entries for this document include: Genetic methods; Thermoregulators; Polymerase chain reaction; and 3 additional concepts. | |
CAPLUS COPYRIGHT 2004 ACS on STN
| TITLE:
| Polynucleotide amplification analysis using a microfabricated device |
| INVENTOR(S):
| Wilding, Peter; Kricka, Larry J. |
| PATENT ASSIGNEE(S):
| University of Pennsylvania, USA |
| SOURCE:
| PCT Int. Appl., 63 pp. CODEN: PIXXD2 |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- --------------- --------
WO 9322058 A1 19931111 WO 1993-US4039 19930429
W: AU, CA, JP
RW: AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE
US 5296375 A 19940322 US 1992-877661 19920501
US 5304487 A 19940419 US 1992-877536 19920501
WO 9322053 A1 19931111 WO 1993-US4013 19930429
W: AU, CA, JP
RW: AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE
AU 9342223 A1 19931129 AU 1993-42223 19930429
AU 677780 B2 19970508
AU 9342235 A1 19931129 AU 1993-42235 19930429
AU 677197 B2 19970417
EP 637996 A1 19950215 EP 1993-910887 19930429
EP 637996 B1 19970723
R: AT, BE, CH, DE, ES, FR, GB, GR, IE, IT, LI, LU, NL
EP 637999 A1 19950215 EP 1993-910907 19930429
EP 637999 B1 19981223
R: AT, BE, CH, DE, ES, FR, GB, GR, IE, IT, LI, LU, NL
JP 07506430 T2 19950713 JP 1993-519499 19930429
JP 3298882 B2 20020708
JP 07506258 T2 19950713 JP 1993-519517 19930429
AT 140025 E 19960715 AT 1993-910890 19930429
AT 140880 E 19960815 AT 1993-910891 19930429
AT 155711 E 19970815 AT 1993-910887 19930429
ES 2106341 T3 19971101 ES 1993-910887 19930429
AT 167816 E 19980715 AT 1993-910889 19930429
AT 174813 E 19990115 AT 1993-910907 19930429
ES 2127276 T3 19990416 ES 1993-910907 19930429
CA 2134475 C 19990706 CA 1993-2134475 19930429
CA 2134478 C 20011218 CA 1993-2134478 19930429
US 5637469 A 19970610 US 1994-347498 19941130
US 5486335 A 19960123 US 1995-427493 19950424
US 5866345 A 19990202 US 1997-811873 19970305
HK 1001305 A1 20011116 HK 1998-100122 19980107
US 6551841 B1 20030422 US 1999-237523 19990127
US 2003129671 A1 20030710 US 2003-348438 20030121
US 2003199081 A1 20031023 US 2003-426674 20030430
ABSTRACT:
Disclosed are devices for amplifying a preselected polynucleotide in a sample by conducting a polynucleotide polymn. reaction. The devices comprise a substrate microfabricated to define a sample inlet port and a mesoscale flow system, which extends from the inlet port. The mesoscale flow system includes a polynucleotide polymn. reaction chamber in fluid communication with the inlet port which is provided with reagents required for polymn. and amplification of a preselected polynucleotide. In one embodiment, the devices may be utilized to implement a polymerase chain reaction (PCR) in the reaction chamber (PCR chamber). The PCR chamber is provided with the sample polynucleotide, polymerase, nucleoside triphosphates, primers, and other reagents required for the polymerase chain reaction, and the device is provided with means for thermally controlling the temp. of the contents of the reaction chamber at a temp. controlled to dehybridize double stranded polynucleotide, to anneal the primers, and to polymerize and amplify the polynucleotide. Diagrams of the app. are included.
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Updated 5/3/2007 11:34:34 AM
