Following is a CAS database record representing a highly cited patent family.
|
CAS indexed 92 chemical substances from this document.
CAS subject entries for this document include: Plasmid and Episome; Gene, animal; Therapeutics; and 6 additional concepts. | |
CAPLUS COPYRIGHT 2004 ACS on STN
| TITLE:
| Humanized antibody against human interleukin-6 receptor |
| INVENTOR(S):
| Tsuchiya, Masayuki; Sato, Koh; Bendig, Mary Margaret; Jones, Steven Tarran; Saldanha, Jose William |
| PATENT ASSIGNEE(S):
| Chugai Seiyaku K. K., Japan |
| SOURCE:
| PCT Int. Appl., 207 pp. CODEN: PIXXD2 |
| LANGUAGE:
| Japanese |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- --------------- --------
WO 9219759 A1 19921112 WO 1992-JP544 19920424
W: AU, BB, BG, BR, CA, CS, FI, HU, JP, KR, LK, MG, MN, MW, NO, PL,
RO, RU, SD, US
RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, DE, DK, ES, FR, GA, GB, GN,
GR, IT, LU, MC, ML, MR, NL, SE, SN, TD, TG
JP 05236966 A2 19930917 JP 1991-95476 19910425
JP 05227970 A2 19930907 JP 1992-32084 19920219
AU 9216740 A1 19921221 AU 1992-16740 19920424
AU 668349 B2 19960502
EP 628639 A1 19941214 EP 1992-909376 19920424
EP 628639 B1 19990623
R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, MC, NL, SE
HU 70258 A2 19950928 HU 1993-3002 19920424
HU 218140 B 20000628
AT 181575 E 19990715 AT 1992-909376 19920424
ES 2134212 T3 19991001 ES 1992-909376 19920424
RU 2139351 C1 19991010 RU 1993-55358 19920424
JP 2001083151 A2 20010330 JP 2000-229748 19920424
JP 3370324 B2 20030127 JP 1992-508898 19920424
SG 99826 A1 20031127 SG 1996-1771 19920424
ZA 9203021 A 19930127 ZA 1992-3021 19920427
US 5795965 A 19980818 US 1993-137117 19931220
US 5817790 A 19981006 US 1995-436717 19950508
AU 9656213 A1 19961024 AU 1996-56213 19960626
AU 692100 B2 19980528
JP 2000116391 A2 20000425 JP 1999-338286 19991129
JP 3176598 B2 20010618
JP 2004045433 A2 20040212 JP 2003-347675 20031006
ABSTRACT:
A reshaped human monoclonal antibody (MAb) to human interleukin-6 receptor (IL-6R) is provided. The light (L) chain of the MAb consists of (1) a variable (V) region that is comprised of a framework (FR) of a human L chain and the complementarity detg. region (CDR) of the L chain of a mouse MAb and (2) a const. (C) region of human L chain. The heavy (H) chain of the MAb is also similarly humanized. The chimeric MAb is useful as a therapeutic agent. Humanizing MAb PM-1 and AUK12-20 using the FR of the L chain of human antibody REI and the FR of te H chain of NEW or HAX by expression of the chimeric genes in animal cells is described.
Updated 5/3/2007 11:30:42 AM
