Following is a CAS database record representing a highly cited patent family.
|
CAS indexed 90 chemical substances from this document.
CAS subject entries for this document include: Antihypertensives; Inflammation inhibitors; Vasodilators; and 2 additional concepts. | |
CAPLUS COPYRIGHT 2003 ACS
| TITLE:
| Therapeutic tetrazolylalkoxycarbostyril derivatives |
| PATENT ASSIGNEE(S):
| Otsuka Pharmaceutical Co., Ltd., Japan |
| SOURCE:
| Belg., 47 pp. CODEN: BEXXAL |
| LANGUAGE:
| French |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- --------------- --------
BE 878548 A1 19791217 BE 1979-196976 19790831
JP 55035019 A2 19800311 JP 1978-107869 19780901
JP 61055514 B4 19861128
CA 1139761 A1 19830118 CA 1979-334272 19790822
DE 2934747 A1 19800313 DE 1979-2934747 19790828
DE 2934747 C2 19880128
AU 7950397 A1 19800306 AU 1979-50397 19790829
AU 538410 B2 19840816
US 4277479 A 19810707 US 1979-70710 19790829
DK 7903631 A 19800302 DK 1979-3631 19790830
DK 158788 B 19900716
DK 158788 C 19901210
FI 7902699 A 19800302 FI 1979-2699 19790830
FI 68398 B 19850531
FI 68398 C 19850910
NL 7906523 A 19800304 NL 1979-6523 19790830
NL 183888 B 19880916
NL 183888 C 19890216
SU 1064868 A3 19831230 SU 1979-2804457 19790830
SE 7907236 A 19800302 SE 1979-7236 19790831
SE 432252 B 19840326
SE 432252 C 19840705
NO 7902829 A 19800304 NO 1979-2829 19790831
NO 153177 B 19851021
NO 153177 C 19860129
FR 2434809 A1 19800328 FR 1979-21869 19790831
FR 2434809 B1 19820917
ZA 7904627 A 19800827 ZA 1979-4627 19790831
ES 483792 A1 19800901 ES 1979-483792 19790831
CH 641799 A 19840315 CH 1979-7920 19790831
GB 2033893 A 19800529 GB 1979-30520 19790903
GB 2033893 B2 19821201
AT 7905845 A 19810315 AT 1979-5845 19790903
AT 364363 B 19811012
ABSTRACT:
Monohydroxycarbostyrils were O-alkylated by 5-(.omega.-haloalkyl)tetrazoles to give (tetrazolylalkoxy)carboxstyrils I and II [R = alkyl, cycloalkyl, cycloalkylalkyl, Ph, phenylalkyl; Z = alkylene (the tetrazolylalkoxy group is in the 4-, 5-, 6-, 7-, or 8-position); R1 = H, alkyl, alkenyl, alkanoyl, benzoyl, phenylalkyl; or R2 = H, alkyl], which inhibited blood platelet aggregation, inhibited cyclic AMP phosphodiesterase, and showed vasodilator activity; I and II are useful as antiinflammatory and anti-ulcer agents (no data). 6-Hydroxycarbostyril reacted with 1-cyclohexyl-5-(3-chloropropyl)tetrazole and K2CO3 in DMF at 70-80.degree. to give the resp. I [R1 = R2 = H, Z = (CH2)3, R = cyclohexyl].
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Updated 5/3/2007 11:16:36 AM
