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Home   •   Spotlight  •  pcite01  •  Most Cited Patent Families 2001-Chemistry and Related (9)

Most Cited Patent Families 2001-Chemistry and Related

Following is a CAS database record representing a highly cited patent family.

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CAS indexed 65 chemical substances from this document. CAS subject entries for this document include: Acquired immune deficiency syndrome; Drug dependence; Headache; and 3 additional concepts.

CAPLUS COPYRIGHT 2002 ACS

TITLE:	Substituted pyrazoles as corticotropin-releasing factor antagonists
INVENTOR(S):	Bright, Gene M.; Welch, Willard M., Jr.
PATENT ASSIGNEE(S):	Pfizer Inc., USA
SOURCE:	PCT Int. Appl., 44 pp. CODEN: PIXXD2
LANGUAGE:	English

PATENT INFORMATION:

PATENT NO.       KIND  DATE           APPLICATION NO.  DATE
---------------  ----  --------       ---------------  --------
WO 9413661        A1   19940623       WO 1993-US9170   19930930
	 W:  AU, BR, CA, CZ, JP, KR, NO, NZ, PL, RU, US
	 RW: AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE
CA 2150703        AA   19940623       CA 1993-2150703  19930930
AU 9351413        A1   19940704       AU 1993-51413    19930930
AU 690079         B2   19980423
EP 674631         A1   19951004       EP 1993-922407   19930930
EP 674631         B1   19991208
    R:  AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LI, LU, NL, PT, SE
PL 175982         B1   19990331       PL 1993-309355   19930930
RU 2130453        C1   19990520       RU 1995-113965   19930930
BR 9307664        A    19990629       BR 1993-7664     19930930
EP 959074         A2   19991124       EP 1999-109027   19930930
EP 959074         A3   20000607
    R:  AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, PT, IE
AT 187451         E    19991215       AT 1993-922407   19930930
ES 2139676        T3   20000216       ES 1993-922407   19930930
CZ 287925         B6   20010314       CZ 1995-1582     19930930
IL 107947         A1   19980816       IL 1993-107947   19931209
ZA 9309406        A    19950615       ZA 1993-9406     19931215
FI 9305672        A    19940618       FI 1993-5672     19931216
HU 65822          A2   19940728       HU 1993-3615     19931216
CN 1093363        A    19941012       CN 1993-120122   19931216
CN 1045293        B    19990929
US 5705646        A    19980106       US 1995-481348   19950614
NO 9502397        A    19950814       NO 1995-2397     19950616
US 5958948        A    19990928       US 1997-933963   19970919

ABSTRACT:
Title compds. [I:R1 = H, (un)branched C1-6 alkyl or alkoxy, OH, SH, C3-6 cycloalkyl, morpholinyl, piperidinyl, etc.; R3 = (un)substituted alkyl, alkenyl, etc.; X1 = direct bond, CH2, O, S, NR; R = H, alkyl; Y = Ph, thienyl, benzothienyl pyridyl, quinolyl, pyrazinolyl, pyrimidinyl, etc.; Z = substituted amino, heterocyclo, (un)substituted alkoxy, heterocyclo, etc.], which have ACTH-releasing factor (CRF) antagonistic activity (no data) and are useful in the treatment of illnesses induced by CRF [e.g., stress- and anxiety-related disorders (no data), etc.], are prepd. Thus, 2-[5-methyl-3-methylthio-1-(2,4,6-trichlorophinyl)pyrazol-4-yl]methyl-1,2,3, 4-tetrahydroisoquinoline hydrochloride, m.p. 205-207.degree. was prepd. in 53% overall yield from Et acetoacetate in 3 steps.

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