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Most Cited Patent Families 2001-Chemistry and Related

Following is a CAS database record representing a highly cited patent family.

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CAS indexed 190 chemical substances from this document. CAS subject entries for this document include: Human immunodeficiency virus; Antibacterial agents; Antiviral agents.

CAPLUS COPYRIGHT 2002 ACS

TITLE:	Properation of novel pyridonecarboxylic acid derivatives as antibacterial agents
INVENTOR(S):	Yazaki, Akira; Niino, Yoshiko; Ohshita, Yoshihiro; Hirao, Yuzo; Amano, Hirotaka; Hayashi, Norihiro; Kuramoto, Yasuhiro
PATENT ASSIGNEE(S):	Wakunaga Pharmaceutical Co., Ltd., Japan; Yazaki, Akira; Niino, Yoshiko; Ohshita, Yoshihiro; Hirao, Yuzo; Amano, Hirotaka; Hayashi, Norihiro; Kuramoto, Yasuhiro
SOURCE:	PCT Int. Appl., 120 pp. CODEN: PIXXD2
LANGUAGE:	Japanese

PATENT INFORMATION:

PATENT NO.       KIND  DATE           APPLICATION NO.  DATE
---------------  ----  --------       ---------------  --------
WO 9711068        A1   19970327       WO 1996-JP2710   19960920
	 W:  AU, BR, CA, CN, HU, JP, KR, MX, RU, US
	 RW: AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE
CA 2232728        AA   19970327       CA 1996-2232728  19960920
AU 9670016        A1   19970409       AU 1996-70016    19960920
AU 707565         B2   19990715
CN 1201459        A    19981209       CN 1996-198104   19960920
EP 911327         A1   19990428       EP 1996-931264   19960920
EP 911327         B1   20011205
    R:  AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT,
	IE, FI
BR 9610485        A    19990727       BR 1996-10485    19960920
EP 952151         A2   19991027       EP 1999-111114   19960920
EP 952151         A3   20010801
    R:  AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT,
	IE, FI
JP 11322715       A2   19991124       JP 1999-107671   19960920
EP 992501         A2   20000412       EP 1999-124494   19960920
EP 992501         A3   20010905
    R:  AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT,
	IE, FI
JP 3103380        B2   20001030       JP 1997-512602   19960920
RU 2167873        C2   20010527       RU 1998-107259   19960920
RU 2171252        C2   20010727       RU 1999-117921   19960920
AT 210129         E    20011215       AT 1996-931264   19960920
US 5998436        A    19991207       US 1998-43472    19980320
AU 9931227        A1   19990812       AU 1999-31227    19990524
AU 721805         B2   20000713
US 6133284        A    20001017       US 1999-329246   19990610
US 6156903        A    20001205       US 1999-329336   19990610
AU 727457         B2   20001214       AU 1999-50144    19990924
AU 9950144        A1   20000330
JP 2000136191     A2   20000516       JP 1999-285235   19991006
JP 3187795        B2   20010711
CN 1258672        A    20000705       CN 1999-123310   19991022
CN 1258674        A    20000705       CN 1999-123311   19991022

 

ABSTRACT:
The title compds. (I; R1 = H, carboxyl protecting group; R2 = OH, lower alkoxy, optionally substituted amino; R3, R4 = H, halo; R5 = optionally halogenated or substituted satd. cyclic amino; R6 = H, halo, NO2, optionally protected amino; X, Y, and Z = N, :CH, :CR7; R7 = lower alkyl, halo, cyano, provided that at least one of X, Y, and Z = N; W = N, :CR8; R8 = H, halo, lower alkyl) are prepd. I are useful as antibacterial, antiviral, and anti-HIV agents. Thus, quinoline deriv. (II; X = F) was reacted with 3-aminoazetidine.2HCl in the presence of N-methylpyrrolidine to give the title compd. II (X = 3-aminoazetidin-1-yl), which showed MIC of < 0.013, 0.025, and 0.05 .mu.g/mL antibacterial effect for S. aureus, S. epidermidis, and P. aeruginosa resp.

 

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