Following is a CAS database record representing a highly cited patent family.
CAS indexed 52 chemical substances from this document.
CAS subject entries for this document include: Antiarteriosclerotics; Anticholesteremic agents; Antidiabetic agents; and 5 additional concepts. |
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CAPLUS COPYRIGHT 2001 ACS
| TITLE:
| Preparation of benzimidazolylalkoxyarenes for treatment of hyperlipemia, hyperglycemia, obesity, impaired glucose tolerance, insulin resistance, and diabetic complications. |
| INVENTOR(S):
| Fujita, Takashi; Wada, Kunio; Oguchi, Minoru; Yanagisawa, Hiroaki; Fujimoto, Koichi; Fujiwara, Toshihiko; Horikoshi, Hiroyoshi; Yoshioka, Takao |
| PATENT ASSIGNEE(S):
| Sankyo Co., Ltd., Japan |
| SOURCE:
| Eur. Pat. Appl., 227 pp. CODEN: EPXXDW |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- --------------- --------
EP 745600 A1 19961204 EP 1996-303940 19960531
R: AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL,
PT, SECA 2177858 AA 19961202 CA 1996-2177858 19960531
NO 9602239 A 19961202 NO 1996-2239 19960531
ZA 9604518 A 19961209 ZA 1996-4518 19960531
AU 9654627 A1 19961212 AU 1996-54627 19960531
AU 712390 B2 19991104
JP 09295970 A2 19971118 JP 1996-137930 19960531
JP 2976885 B2 19991110
RU 2125048 C1 19990120 RU 1996-110410 19960531
JP 2000001487 A2 20000107 JP 1999-150312 19960531
CN 1157288 A 19970820 CN 1996-110937 19960601
ABSTRACT:
Title compds. [I; X = (substituted) benzimidazolyl; Y = O, S; Z = 2,4-dioxothiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxo-oxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl, CH2N(OH)CONH2; R = H, alkyl, alkoxy, halo, OH, NO2, amino, aralkyl; m = 1-5], were prepd. Thus, N-methyl-1,2-phenylenediamine and 5-[4-(ethoxycarbonylmethoxy)benzyl]thiazolidine-2,4-dione (prepn. given) were refluxed 5 h in aq. HCl/dioxane to give 5-[4-(1-methylbenzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione. The latter at 5 .mu.g/mL gave 80.3% inhibition of bovine lens aldose reductase.
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