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Most Cited Journal Articles 1999-Medical Sciences

 

Following is a CAS database record representing a highly cited journal article.

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CAS indexed 2 chemical substances from this document.

CAPLUS COPYRIGHT 2002 ACS

TITLE:	Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide
AUTHOR(S):	Beckman, Joseph S.; Beckman, Tanya W.; Chen, Jun; Marshall, Patricia A.; Freeman, Bruce A.
CORPORATE SOURCE:	Dep. Anesthesiol., Univ. Alabama, Birmingham, AL, 35233, USA
SOURCE:	Proceedings of the National Academy of Sciences of the United States of America (1990), 87(4), 1620-4 CODEN: PNASA6; ISSN: 0027-8424
PUBLISHER:	National Academy of Sciences
LANGUAGE:	English

ABSTRACT:
Peroxynitrite has a pKa of 7.49 at 37.degree. and rapidly decomps. once protonated with a half-life of 1.9 s at pH 7.4. Peroxynitrite decompn. generates a strong oxidant with reactivity similar to hydroxyl radical, as assessed by the oxidn. of deoxyribose or DMSO. Product yields indicative of hydroxyl radical were 5.1 and 24.3%, resp., of added peroxynitrite. Product formation was not affected by the metal chelator diethyltriaminepentaacetic acid, suggesting that iron was not required to catalyze oxidn. In contrast, desferrioxamine was a potent, competitive inhibitor of peroxynitrite-initiated oxidn. because of a direct reaction between desferrioxamine and peroxynitrite rather than by iron chelation. Superoxide dismutase may protect vascular tissue stimulated to produce superoxide and NO under pathol. conditions by preventing the formation of peroxynitrite.

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