CAS Science Spotlight Most Cited Journal Articles 2005-Medical Sciences


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Most Cited Journal Articles 2005-Medical Sciences

Following is a CAS database record representing a highly cited journal article.

CAS subject entries for this document include: Proteins; Receptors; Signal transduction, biological; and 1 additional concept.

TITLE:	Toll-like receptors
AUTHOR(S):	Takeda, Kiyoshi; Kaisho, Tsuneyasu; Akira, Shizuo
CORPORATE SOURCE:	Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, 565-0871, Japan
SOURCE:	Annual Review of Immunology (2003), 21, 335-376 CODEN: ARIMDU; ISSN: 0732-0582
PUBLISHER:	Annual Reviews Inc.
LANGUAGE:	English

ABSTRACT:
A review. The innate immune system in drosophila and mammals senses the invasion of microorganisms using the family of Toll receptors, stimulation of which initiates a range of host defense mechanisms. In drosophila antimicrobial responses rely on two signaling pathways: the Toll pathway and the IMD pathway. In mammals there are at least 10 members of the Toll-like receptor (TLR) family that recognize specific components conserved among microorganisms. Activation of the TLRs leads not only to the induction of inflammatory responses but also to the development of antigenspecific adaptive immunity. The TLR-induced inflammatory response is dependent on a common signaling pathway that is mediated by the adaptor mol. MyD88. However, there is evidence for addnl. pathways that mediate TLR ligand-specific biol. responses.

Updated 4/27/2007 9:06:08 AM