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Most Cited Journal Articles 2005-Medical Sciences

Following is a CAS database record representing a highly cited journal article.

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CAS subject entries for this document include: Lymphocyte; Antigen presentation; Antigen processing; and 4 additional concepts.

CAPLUS COPYRIGHT 2006 ACS on STN

TITLE:	Immunobiology of dendritic cells
AUTHOR(S):	Banchereau, Jacques; Briere, Francine; Caux, Christophe; Davoust, Jean; Lebecque, Serge; Liu, Yong-Jun; Pulendran, Bali; Palucka, Karolina
CORPORATE SOURCE:	Baylor Institute for Immunology Research, Dallas, TX, 75204, USA
SOURCE:	Annual Review of Immunology (2000), 18, 767-811 CODEN: ARIMDU; ISSN: 0732-0582
PUBLISHER:	Annual Reviews Inc.
LANGUAGE:	English

ABSTRACT:
A review with 289 refs. Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary immune responses. DCs capture and transfer information from the outside world to the cells of the adaptive immune system. DCs are not only crit. for the induction of primary immune responses, but may also be important for the induction of immunol. tolerance, as well as for the regulation of the type of T cell-mediated immune response. Although the authors' understanding of DC biol. is still in its infancy, the authors are now beginning to use DC-based immunotherapy protocols to elicit immunity against cancer and infectious diseases.