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Most Cited Journal Articles 2004-Medical Sciences

Following is a CAS database record representing a highly cited journal article.

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CAS subject entries for this document include: Angiogenesis; Gene, animal; Neoplasm; and 1 additional concept.

CAPLUS COPYRIGHT 2005 ACS on STN

TITLE:	The hallmarks of cancer
AUTHOR(S):	Hanahan, Douglas; Weinberg, Robert A.
CORPORATE SOURCE:	Department of Biochemistry and Biophysics and Hormone Research Institute, University of California at San Francisco, San Francisco, CA, 94143, USA
SOURCE:	Cell (Cambridge, Massachusetts) (2000), 100(1), 57-70 CODEN: CELLB5; ISSN: 0092-8674
PUBLISHER:	Cell Press
LANGUAGE:	English

ABSTRACT:
A review is given with many refs. on principles governing the transformation of normal human cells into malignant cancers. The authors suggest that research over the past decades has revealed a small no. of mol., biochem., and cellular traits (acquired capabilities) shared by most and perhaps all types of cancer. Topics included are the acquired capabilities self-sufficiency in growth signals, insensitivity to antigrowth signals, evading apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis followed by genome instability as an enabling characteristic and alternative pathways to cancer.