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Most Cited Journal Articles 2002-Medical Sciences

Following is a CAS database record representing a highly cited journal article.

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CAS subject entries for this document include: Blood vessel, disease; Disease; Neoplasm; and 2 additional concepts.

CAPLUS COPYRIGHT 2003 ACS

TITLE:	Angiogenesis in cancer, vascular, rheumatoid and other disease
AUTHOR(S):	Folkman, Judah
CORPORATE SOURCE:	Children's Hospital and Harvard Medical Sch., Boston, MA, USA
SOURCE:	Nature Medicine (New York) (1995), 1(1), 27-31 CODEN: NAMEFI; ISSN: 1078-8956
PUBLISHER:	Nature Publishing Co.
LANGUAGE:	English

ABSTRACT:
A review with .apprx.72 refs. Recent discoveries of endogenous neg. regulators of angiogenesis, thrombospondin, angiostatin and glioma-derived angiogenesis inhibitory factor, all assocd. with neovascularized tumors, suggest a new paradigm of tumorigenesis. It is now helpful to think of the switch to the angiogenic phenotype as a net balance of pos. and neg. regulators of blood vessel growth. The extent to which the neg. regulators are decreased during this switch may dictate whether a primary tumor grows rapidly or slowly and whether metastases grow at all.