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Home   •   Spotlight  •  medsci01  •  Most Cited Journal Articles 2001-Medical Sciences (7)

Most Cited Journal Articles 2001-Medical Sciences

Following is a CAS database record representing a highly cited journal article.

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CAS indexed 2 chemical substances from this document. CAS subject entries for this document include: Apoptosis; Signal transduction, biological; Platelet-derived growth factors; and 4 additional concepts.

CAPLUS COPYRIGHT 2002 ACS

TITLE:	Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
AUTHOR(S):	Datta, Sandeep Robert; Dudek, Henryk; Tao, Xu; Masters, Shane; Fu, Haian; Gotoh, Yukiko; Greenberg, Michael E.
CORPORATE SOURCE:	Division of Neuroscience Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA
SOURCE:	Cell (Cambridge, Massachusetts) (1997), 91(2), 231-241 CODEN: CELLB5; ISSN: 0092-8674
PUBLISHER:	Cell Press
LANGUAGE:	English

ABSTRACT:
Growth factors can promote cell survival by activating the phosphatidylinositide-3'-OH kinase and its downstream target, the serine-threonine kinase Akt. However, the mechanism by which Akt functions to promote survival is not understood. The authors show that growth factor activation of the PI3'-K/Akt signaling pathway culminates in the phosphorylation of the BCL-2 family member BAD, thereby suppressing apoptosis and promoting cell survival. Akt phosphorylates BAD in vitro and in vivo, and blocks the BAD-induced death of primary neurons in a site-specific manner. These findings define a mechanism by which growth factors directly inactivate a crit. component of the cell-intrinsic death machinery.