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Home   •   Spotlight  •  medsci01  •  Most Cited Journal Articles 2001-Medical Sciences (2)

Most Cited Journal Articles 2001-Medical Sciences

Following is a CAS database record representing a highly cited journal article.

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CAS subject entries for this document include: Antigen presentation; Antigen processing; Dendritic cell; and 1 additional concept.

CAPLUS COPYRIGHT 2002 ACS

TITLE:	Dendritic cells and the control of immunity
AUTHOR(S):	Banchereau, Jacques; Steinman, Ralph M.
CORPORATE SOURCE:	Baylor Inst. for Immunol., Res., Baylor Res. Inst., Dallas, TX, 75246, USA
SOURCE:	Nature (London) (1998), 392(6673), 245-252 CODEN: NATUAS; ISSN: 0028-0836
PUBLISHER:	Macmillan Magazines
LANGUAGE:	English

ABSTRACT:
A review with 103 refs. B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic cells in the periphery capture and process antigens, express lymphocyte co-stimulatory mols., migrate to lymphoid organs, and secrete cytokines to initiate immune responses. They not only activate lymphocytes, they also tolerize T cells to antigens that are innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow mol. and cell biol. anal. With knowledge comes the realization that these cells are a powerful tool for manipulating the immune system.

View the full-text pdf document from the Nature Publishing Group.