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Most Cited Journal Articles 2001-Medical Sciences

Following is a CAS database record representing a highly cited journal article.

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CAS subject entries for this document include: Cyclins; Transcription factors; Cyclin dependent kinase inhibitors; and 3 additional concepts.

CAPLUS COPYRIGHT 2002 ACS

TITLE:	Cancer cell cycles
AUTHOR(S):	Sherr, Charles J.
CORPORATE SOURCE:	Howard Hughes Med. Inst., St. Jude Children's Res. Hospital, Memphis, TN, 38105, USA
SOURCE:	Science (Washington, D. C.) (1996), 274(5293), 1672-1677 CODEN: SCIEAS; ISSN: 0036-8075
PUBLISHER:	American Association for the Advancement of Science
LANGUAGE:	English

ABSTRACT:
A review, with 80 refs. Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically acquired damage to genes that directly regulate their cell cycles. Genetic alterations affecting p16INK4a and cyclin D1, proteins that govern phosphorylation of the retinoblastoma protein (RB) and control exit from the G1 phase of the cell cycle, are so frequent in human cancers that inactivate of this pathway may well be necessary for tumor development. Like the tumor suppressor protein p53, components of this "RB pathway," although not essential for the cell cycle per se, may participate in checkpoint functions that regulate homeostatic tissue renewal throughout life.

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