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Most Cited Journal Articles 2000-Medical Sciences

 

Following is a CAS database record representing a highly cited journal article.

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CAS indexed 11 chemical substances from this document. CAS subject entries for this document include: Blood pressure; Gene and Genetic element, animal; Amino acids, biological studies; and 4 additional concepts.

CAPLUS COPYRIGHT 2002 ACS

TITLE:	A novel potent vasoconstrictor peptide produced by vascular endothelial cells
AUTHOR(S):	Yanagisawa, Masashi; Kurihara, Hiroki; Kimura, Sadao; Tomobe, Yoko; Kobayashi, Mieko; Mitsui, Youji; Yazaki, Yoshio; Goto, Katsutoshi; Masaki, Tomoh
CORPORATE SOURCE:	Inst. Basic Med. Sci., Univ. Tsukuba, Ibaraki, 305, Japan
SOURCE:	Nature (London) (1988), 332(6163), 411-15 CODEN: NATUAS; ISSN: 0028-0836
PUBLISHER:	Macmillan Magazines
LANGUAGE:	English

ABSTRACT:
An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, was isolated from the culture supernatant of porcine aortic endothelial cells and was shown to be one of the most potent vasoconstrictors known. The 50% EC for endothelin on porcine right coronary artery strips was 4.0 .times. 10-10M. The cloning and sequencing of preproendothelin cDNA showed that mature endothelin is generated through unusual proteolytic processing, and regional homologies to a group of neurotoxins suggested that endothelin is an endogenous modulator of voltage-dependent ion channels. Expression of the endothelin gene was regulated by several vasoactive agents (thrombin, A 23187, and adrenaline), indicating the existence of a novel cardiovascular control system.

View the full-text pdf document from the Nature Publishing Group.