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Most Cited Journal Articles 2003-Chemistry and Related

Following is a CAS database record representing a highly cited journal article.

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CAS indexed 1 chemical substance from this document. CAS subject entries for this document include: Coliphage T4; Polyacrylamide gel electrophoresis; Proteins, specific or class.

CAPLUS COPYRIGHT 2004 ACS on STN

TITLE:	Cleavage of structural proteins during the assembly of the head of bacteriophage T4
AUTHOR(S):	Laemmli, U. K.
CORPORATE SOURCE:	MRC Laboratory of Molecular Biology, Cambridge, UK
SOURCE:	Nature (London, United Kingdom) (1970), 227(5259), 680-685 CODEN: NATUAS; ISSN: 0028-0836
PUBLISHER:	Nature Publishing Group
LANGUAGE:	English

ABSTRACT:
Using an improved method of polyacrylamide gel electrophoresis based on the capability of SDS to break down proteins into their individual polypeptide chains, many previously unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products. Four major components of the head are cleaved during the process of assembly, apparently after the precursor proteins have assembled into some large intermediate structure.

View the full-text pdf document from the Nature Publishing Group.