December 31, 2012

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.  

The following patent record is from the CAplusSM database.


Patent Number: WO 2012143813
Title: Preparation of spiro[indazole-5,4'-piperidin]-1'-yl compounds as acetyl-CoA carboxylase inhibitors
Inventor(s): Dow, Robert Lee; Edmonds, David James; Griffith, David Andrew; Southers, James Alfred, Jr.
Patent Assignee(s): Pfizer Inc., USA
Source: U.S. Pat. Appl. Publ., 73pp. CODEN: USXXCO
Language: English


Title compds. I and II [R1 = alkyl or cylcoalkyl; R2 = (un)substituted indolyl, indazolyl, pyrrolopyridinyl, pyrazolopyridinyl, quinolinyl or benzoimidazolyl; R3 = H or alkyl], and their pharmaceutically acceptable salts, are prepared as acetyl-CoA carboxylase (ACC) inhibitors. Thus, e.g., compound III was prepared by the coupling reaction of 1-isopropyl-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one (preparation given) with 3-carbamoyl-1H-indole-6-carboxylic acid (preparation given). Compound III exhibited  inhibitory activity against recombinant human ACC1 and ACC2 with IC50 values of 6.0 nM and 1.4 nM, resp. The  invention compds. are useful for the treatment of acetyl-CoA carboxylase associated diseases such as type 2 diabetes and nonalcoholic fatty liver disease (NAFLD).

View the full-text patent here.

Note: Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention. In this example, CAS enhanced the abstract using additional information found in the patent. The title of the PCT patent publication is Substituted acetyl-CoA carobxylase inhibitors.

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