December 17, 2012

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.  

The following patent record is from the CAplusSM database.


Patent Number: US 8273897
Title: Preparation of 2,2-difluoroethylamines via amide hydrogenation 
Inventor(s): Lui, Norbert; Antons, Stefan
Patent Assignee(s): Bayer CropScience A.-G., Germany
Source: PCT Int. Appl., 24 pp. CODEN: PIXXD2
Language: German


A process for the preparation of title compds. I [A = pyrid-2-yl, pyrid-4-yl, etc.] via the hydrogenation of amides II was disclosed.  For example, NaBH4/BF3 mediated reduction of amide III [X = O] afforded difluoroethylamine III [X = H] in 95% yield.

View the full-text USPTO patent here.

Note: Abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. CAS enhanced the abstract using additional information found in the patent.

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