November 26, 2012

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2012 ACS

Patent Number: US 8273735
Title: Process for preparation of benzoylaminobenzoylbenzazepinones by reaction of benzazepinones with benzoylaminophenyl halides in the presence of carbonylating agents.
Inventor(s): Torisawa, Yasuhiro; Abe, Kaoru; Muguruma, Yasuaki; Fujita, Shigekazu; Ogawa, Hidenori; Utsumi, Naoto; Miyake, Masahiro
Patent Assignee(s): Otsuka Pharmaceutical Co., Ltd., Japan
Source: PCT Int. Appl., 44pp. CODEN: PIXXD2
Language: English

Abstract:
The Title compds. (I; X1 = halo; R1, R2 = alkyl) were prepared by reaction of benzazepinones (II; X1 as above) with halides (III; R1, R2 as above; X2 = halo) in the presence of a carbonylating agent.  Thus, a mixture of 2-bromo-5-(2-methylbenzoylamino)toluene (preparation given), 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one, DBU, Ph3P, and Pd(OAc)2 in DMF was heated under CO at 125ー for 3 h to give 85% 7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one of 99.1% purity.

View the full-text USPTO patent here.

Note: Titles and abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. In this example, CAS enhanced both the abstract and title using additional information found in the patent. The original title of the U.S. granted patent is Process for preparing bezazepine compounds or salts thereof. For the CAplus record, this title was enhanced to read Process for preparation of benzoylaminobenzoylbenzazepinones by reaction of benzazepinones with benzoylaminophenyl halides in the presence of carbonylating agents.

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