November 18, 2013

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The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2013 ACS

Patent Number: WO 2013144532
Title: Preparation of cyanoarylaminocycloalkylaminopyrrolo-pyrimidine derivatives for use as antitumor agents
Inventor(s): Chuaqui, Claudio Edmundo; Dowling, James Edward; Lyne, Paul; Pontz, Timothy; Ye, Qing
Patent Assignee(s): AstraZeneca AB, Swed.; AstraZeneca UK Limited
Source: PCT Int. Appl., 52pp. CODEN: PIXXD2
Language: English

Abstract:
Title compds. I [R1 = N(CH3)(CH2)2NH2 or N(CH3)(CH2)2N(CH3)2; R2 = cycloalkyl], and their pharmaceutically acceptable salts, are prepd. and disclosed as antitumor agents.  Thus, e.g., II was prepd. by a multistep procedure (prepn. given).  I were evaluated in CK2 enzyme inhibition activity assays, e.g., II demonstrated an IC50 value of <0.004 mM.

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.

 View the full-text here.

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