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CAPLUS COPYRIGHT 2013 ACS
||Preparation of cyanoarylaminocycloalkylaminopyrrolo-pyrimidine derivatives for use as antitumor agents
||Chuaqui, Claudio Edmundo; Dowling, James Edward; Lyne, Paul; Pontz, Timothy; Ye, Qing
||AstraZeneca AB, Swed.; AstraZeneca UK Limited
||PCT Int. Appl., 52pp. CODEN: PIXXD2
Title compds. I [R1 = N(CH3)(CH2)2NH2 or N(CH3)(CH2)2N(CH3)2; R2 = cycloalkyl], and their pharmaceutically acceptable salts, are prepd. and disclosed as antitumor agents. Thus, e.g., II was prepd. by a multistep procedure (prepn. given). I were evaluated in CK2 enzyme inhibition activity assays, e.g., II demonstrated an IC50 value of <0.004 mM.
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