November 18, 2013

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.


Patent Number: WO 2013144532
Title: Preparation of cyanoarylaminocycloalkylaminopyrrolo-pyrimidine derivatives for use as antitumor agents
Inventor(s): Chuaqui, Claudio Edmundo; Dowling, James Edward; Lyne, Paul; Pontz, Timothy; Ye, Qing
Patent Assignee(s): AstraZeneca AB, Swed.; AstraZeneca UK Limited
Source: PCT Int. Appl., 52pp. CODEN: PIXXD2
Language: English

Title compds. I [R1 = N(CH3)(CH2)2NH2 or N(CH3)(CH2)2N(CH3)2; R2 = cycloalkyl], and their pharmaceutically acceptable salts, are prepd. and disclosed as antitumor agents.  Thus, e.g., II was prepd. by a multistep procedure (prepn. given).  I were evaluated in CK2 enzyme inhibition activity assays, e.g., II demonstrated an IC50 value of <0.004 mM.

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.

 View the full-text here.

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