November 18, 2013

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2013 ACS

Patent Number: WO 2013144532
Title: Preparation of cyanoarylaminocycloalkylaminopyrrolo-pyrimidine derivatives for use as antitumor agents
Inventor(s): Chuaqui, Claudio Edmundo; Dowling, James Edward; Lyne, Paul; Pontz, Timothy; Ye, Qing
Patent Assignee(s): AstraZeneca AB, Swed.; AstraZeneca UK Limited
Source: PCT Int. Appl., 52pp. CODEN: PIXXD2
Language: English

Abstract:
Title compds. I [R1 = N(CH3)(CH2)2NH2 or N(CH3)(CH2)2N(CH3)2; R2 = cycloalkyl], and their pharmaceutically acceptable salts, are prepd. and disclosed as antitumor agents.  Thus, e.g., II was prepd. by a multistep procedure (prepn. given).  I were evaluated in CK2 enzyme inhibition activity assays, e.g., II demonstrated an IC50 value of <0.004 mM.

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.

 View the full-text here.

Recent News

    
    August 21, 2016 | CAS announces SciFindern, a new
    research experience that elevates scientific discovery

    August 19, 2016 | CAS seeks to help undergraduate
    students think like researchers with Chemistry
    Class Advantage, an organic chemistry learning
    solution powered by SciFinder

    August 1, 2016 | CAS Strengthens its Commitment to
    Science and Innovation Selecting 26 Outstanding
    International Scientists to Participate in the 2016
    SciFinder Future Leaders Program

 
                                                                    More News >> 
 
 

Media Contact

 Name: Rhonda Ross
 Phone: 614-447-3624
 Email: cas-pr@cas.org