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The following patent record is from the CAplusSM
CAPLUS COPYRIGHT 2012 ACS
|Patent Number: ||US 8252927 |
|Title: ||Synthesis of substituted 4-aminopyrimidines as intermediates of vitamin B1 |
|Inventor(s): ||Karge, Reinhard; Letinois, Ulla; Schiefer, Gerhard |
|Patent Assignee(s): ||DSM IP Assets B.V., Neth. |
|Source: ||PCT Int. Appl., 28pp. CODEN: PIXXD2 |
|Language: ||English |
The present invention is directed to a process for the manufacture of 4-aminopyrimidines of formula I [R1 = amino protecting group; R2 = H, alkyl] via (a) reacting a compound of formula II [M+ = cation] with an ammonium salt to give III and (b) cyclization of III with an alkyl nitrile. The present invention is further directed to compds. of formula III and their use for the manufacture of vitamin B1.
View the full-text USPTO patent here.
Note: Titles and abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. In this example, CAS enhanced both the abstract and title using additional information found in the patent. The original title of the U.S. granted patent is Synthesis of substituted 4-aminopyrimidines. For the CAplus record, this title was enhanced to read Synthesis of substituted 4-aminopyrimidines as intermediates of vitamin B1.