November 7, 2011

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 61 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2011 ACS

Patent Number: US 8026395
Title: Process for the synthesis of anti-neoplasia agent VNP40101M
Inventor(s): Lin, Xu; King, Ivan
Patent Assignee(s): Nanotherapeutics, Inc., USA
Source: U.S., 10pp. CODEN: USXXAM
Language: English

Abstract:
The present invention relates to simple, safe, high-yield methods of synthesizing VNP40101M, 1,2-bis(methylsulfonyl)-2-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine, an anti-neoplasia agent.  One particularly preferred method uses Me chloroformamide in a one-pot reaction at elevated temps. to provide VNP40101M in high yield.

View the full-text U.S. patent from USPTO.

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