October 21, 2013

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.


Patent Number: WO 2013123277
Title: Preparation of tricyclic indole derivatives useful as endothelial lipase inhibitors
Inventor(s): Connelly, Margery A.; Greco, Michael; Ye, Hong
Patent Assignee(s): Janssen Pharmaceutica, NV, Belg.
Source: U.S. Pat. Appl. Publ., 30pp. CODEN: USXXCO
Language: English

The present invention is directed to tricyclic indole derivs. I [R1 = (CH2)a-Ph, (CH2)b-O-phenyl; a = 1-5; b = 1-4; Ph of group R1 can be optionally substituted with halo, alkyl, alkoxy; R2 = H, OH, OMe, NH2; ring A = 5-7 membered, satd. ring structure selected from II-VII; R3 = H, alkyl, alkyl-OH, etc.; with the provisos], pharmaceutical compns. contg. them and their use in the treatment of disorders and conditionsmodulated by endothelial lipase, for example, cardiovascular disorders.  Over twenty compds. I were prepd.  E.g., a multi-step synthesis of VIII, starting from 2-ethoxy-3-phenethyl-2-(trifluoromethyl)oxirane and 2,3,4,5-tetrahydro-1H-benzo[b]azepine, was described.  Exemplified compds. I were tested in the endothelial lipase assay (data given).

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.

 View the full-text here.

Recent News

    September 1, 2015 | BizInt Smart Charts and New
    STN Collaboration Extends and Optimizes Intellectual
    Property Search Workflow

    August 7, 2015 | CAS Announces the 2015 SciFinder
    Future Leaders in Chemistry and First-Ever Alumni
    August 3, 2015 | New STN Breaks Ground with
    Markush Structure Search and Enhanced Content
    for Intellectual Property Exploration and Research
                                                                    More News >> 

Media Contact

 Name: Rhonda Ross
 Phone: 614-447-3624
 Email: cas-pr@cas.org