October 17, 2011

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The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2011 ACS

Patent Number: US 8026363
Title: Process for producing di-o-methylcoelenteramide or a derivative thereof
Inventor(s): Inouye, Satoshi
Patent Assignee(s): Chisso Corporation, Japan
Source: Brit. UK Pat. Appl., 76pp. CODEN: BAXXDU
Language: English
Abstract:
Di-O-methylcoelenteramide I [R1 = R4 = Me, R3 = CH2Ph] and analogs I [R1, R4 = alkyl, arylalkyl, etc.; R3 = alkyl, arylalkyl, carbocyclylalkyl] were prepared by reacting O-methylcoelenteramine II [R1 = Me, R3 = CH2Ph] or its analogs with 4-methoxyphenylacetyl halide or a derivative thereof, such as R4O-4-C6H4CH2COX [R4 = alkyl arylalkyl, X = halide].  Also outlined was a method for producing green fluorescent protein (gFP) by reacting coelenteramide or a derivative thereof with the apoprotein of a calcium-binding photoprotein in the presence of a chelating agent, preferably EDTA for sequestering a calcium ion or a divalent or trivalent ion suitable for calcium. The blue fluorescent protein may be formed by reacting O-methylcoelenteramine or its analog with 4-methoxyphenylacetyl halide or a derivative thereof and reacting this compound with the apoprotein of a calcium-binding photoprotein, in the presence of a calcium ion or a divalent or trivalent ion suitable for calcium.

Please note:  Titles and abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. In this example, CAS enhanced both the abstract and title using additional information found in the patent. The original title of the U.S. granted patent is Process for producing coelenteramide or an analog thereof. For the CAplus record, this title was enhanced to read Process for producing di-o-methylcoelenteramide or a derivative thereof. CAS originally indexed the UK published application (GB 2467632) as the first published record of the invention which was originally assigned to Chisso Corp. It was subsequently reassigned on 20110427 to JNC Corp., which is what is shown on the granted patent US 8026363 published on 20110927.

View the full-text U.S. patent from USPTO

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