October 1, 2012

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2012 ACS

Patent Number: WO 2012097269
Title: Preparation of pyrimidinyltetrahydrofuranylbenzimidazolylurea derivatives for use as gyrase and topoisomerase IV inhibitors useful in treatment of bacterial infections
Inventor(s): Le Tiran, Arnaud; Grillot, Anne-Laure; Charifson, Paul S.; Bennani, Youssef Laafiret; O'Dowd, Hardwin; Perola, Emanuele
Patent Assignee(s): Vertex Pharmaceuticals Incorporated, USA
Source: PCT Int. Appl., 149pp. CODEN: PIXXD2
Language: English

Abstract:
Title compds. I [X = H, PO(OH)2, PO(OH)O-M+, PO(O-)2-2M+, or PO(O-)2-D2+; R1 = H or F; M+ = pharmaceutically acceptable monovalent cation; D2+ = pharmaceutically acceptable divalent cation], and their pharmaceutically acceptable salts, are prepared and disclosed as gyrase and topoisomerase IV inhibitors useful in treatment of bacterial infections.  Thus, e.g., II was prepared by a multistep procedure (preparation given).  Select I were evaluated in MIC90 assays (data given).

Please note:  Titles and abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. In this example, CAS enhanced both the abstract and title using additional information found in the patent. The original title of the PCT publication is Pyrimidine gyrase and topoisomerase IV inhibitors. For the CAplus record, this title was enhanced to read Preparation of pyrimidinyltetrahydrofuranylbenzimidazolylurea derivatives for use as gyrase and topoisomerase IV inhibitors useful in treatment of bacterial infections.

 View the full-text here.

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