September 23, 2013

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The following patent record is from the CAplusSM database.


Patent Number: WO 2013096093
Title: Preparation of triazolylpyridine derivatives and analogs for use as DGAT-1 inhibitors
Inventor(s): Devita, Robert J.; He, Shuwen; Liu, Jian; Cernak, Timothy A.; Krikorian, Arto D.; Yang, Ginger Xuqiang; Wu, Zhicai; Yu, Yang; Shen, Dong-Ming; Lai, Zhong; Hong, Qingmei; Nargund, Ravi P.
Patent Assignee(s): Merck Sharp & Dohme Corp., USA
Source: PCT Int. Appl., 119pp. CODEN: PIXXD2
Language: English

Title compds. I [T = bond or O; U = (un)substituted Ph, pyridinyl, pyrimidinyl, etc.; V and X independently = CH or N; Y and Z independently = N, CH, or CR2; R1 = alkoxy, (un)substituted pyridinyl, cyclohexanyl, etc.; R2 = (un)substituted alkyl, Ph, cycloalkyl, etc.; R3 = halo, CN, alkyl or alkoxy and is optionally present at one of more of the ring carbons; provided at least one X, Y, or Z is N], and their pharmaceutically acceptable salts, are prepd. and disclosed as DGAT-1 inhibitors.  Thus, e.g., II was prepd. by a multistep procedure (prepn. given).  Select I were evaluated in hDGAT1 assays (data given).

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.

 View the full-text here.

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