August 5, 2013

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2013 ACS

Patent Number: US 8450482
Title: Process for preparation of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quinazoline
Inventor(s): Boardman, Kay Alison; Cunningham, Oliver Robert; Goundry, William; Laffan, David Dermot Patrick
Patent Assignee(s): AstraZeneca AB, Swed.; AstraZeneca UK Limited
Source: PCT Int. Appl., 46 pp. CODEN: PIXXD2
Language: English

Abstract:
The present invention pertains to a process for the prepn. of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quinazoline and salts thereof.  For example, 2-[4-(4-amino-5-cyano-2-methoxyphenoxy)piperidin-1-yl]-N-methylacetamide (prepn. given) was reacted with N,N-dimethylformamide di-Me acetal in 2-methyltetrahydrofuran in the presence of acetic acid at 76 °C for 16 h to afford 2-[4-[5-cyano-4-[[(dimethylamino)methylene]amino]-2-methoxyphenoxy]piperidin-1-yl]-N-methylacetamide.  The intermediate obtained above was reacted with 3-chloro-2-fluoroaniline in methoxybenzene in the presence of acetic acid at 90°C for 20 h to give the title compd. as the final product.  Pharmaceutical formulations contg. the title compd. as an active ingredient were also disclosed in the present invention.

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.

 View the full-text here.

Recent News

 
    April 17, 2014 | Multi-Year Deal Secures SciFinder
    Access for Prague Consortium Researchers

    April 16, 2014 | New Format Adopted for Taiwanese
    Granted Patent Numbers in CAS Databases and
    INPADOC

    March 26, 2014 | New STN Platform Enhancements
    Available, Increase Efficiency of Search Workflow

                                                                       More News >> 

 Media Contact

 Name: Rhonda Ross
 Phone: 614-447-3624                                       
 Email: cas-pr@cas.org