July 30, 2012

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The following patent record is from the CAplusSM database.


Patent Number: US 8188086
Title: Trihydrochloride forms of a dihydropteridinone derivative and processes for preparation
Inventor(s): Grauert, Matthias; Linz, Guenter; Schmid, Rolf; Sieger, Peter
Patent Assignee(s): Boehringer Ingelheim International G.m.b.H., Germany; Boehringer Ingelheim Pharma G.m.b.H. & Co. K.-G.
Source: PCT Int. Appl., 45pp. CODEN: PIXXD2
Language: English

The invention relates to a specific salt of a dihydropteridinone derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide (I), to its crystallization in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition. The compound was prepared by a multistep procedure (procedure given). This compound may be useful in the treatment of excessive and abnormal cell proliferation.

Please note:  Abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. CAS enhanced the abstract using additional information found in the patent. In this example, CAS indexed the PCT patent publication WO2007090844 as the first published record of the invention with the title: Trihydrochloride forms of a dihydropteridinone derivative and processes for preparation.


View the full-text U.S. patent from USPTO.

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