July 28, 2014

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2014 ACS

Patent Number: WO 2014081689
Title: Preparation of N-substituted triazolamines as inhibitors of indoleamine 2,3-dioxygenase
Inventor(s): Boyall, Dean; Davis, Christopher; Dodd, James; Everitt, Simon; Miller, Andrew; Weber, Peter; Westcott, James; Young, Stephen
Patent Assignee(s): Vertex Pharmaceuticals Incorporated, USA
Source: PCT Int. Appl., 95pp. CODEN: PIXXD2
Language: English

Abstract:
The present invention relates to compds. I [n = 0-4; X = halo; Z1-Z3 = CH or N; R1 = halo, CN, 3-7 membered monocyclic fully satd., partially unsatd., or arom. ring contg. 0-3 heteroatoms independently selected from N, O, or S, etc.] useful as inhibitors of indoleamine 2,3-dioxygenase (IDO).  Forty-eight compds. I were prepd.  E.g., a 2-step synthesis of II, starting from 5-amino-2-chloro-benzonitrile and 2-aminoacetonitrile, was described.  Exemplified compds. I were evaluated as inhibitors of IDO1 (data given).  This invention also relates to pharmaceutically acceptable compns. comprising the compds. I; to methods of treating of various diseases, disorders, and conditions using the compds. I; to processes for prepg. I; to intermediates for the prepn. of I; and methods of using the compds. I in in vitro applications.

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.

 

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