July 15, 2013

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The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2013 ACS

Patent Number: WO 2013062947
Title: Preparation of amide derivatives of N-urea substituted amino acids and dipeptides as N-formyl peptide receptor like-1 (FPRL-1) modulators
Inventor(s): Beard, Richard L.; Duong, Tien T.; Donello, John E.; Viswanath, Veena; Garst, Michael E.
Patent Assignee(s): Allergan, Inc., USA
Source: PCT Int. Appl., 119pp. CODEN: PIXXD2
Language: English

Abstract:
The invention is related to the prepn. of novel amide derivs. of N-urea substituted amino acids I [X = (C:O)a; Y = (CR9aR10a)b; a = 1 and b = 0; a = 0 and b = 1; a = 1 and b = 1; R1 = (un)substituted alkyl, heterocyclyl, aryl, etc.; R2 = (un)substituted alkyl, aryl; R3-4, R6-7 = independently H, halo, NO2, (un)substituted cycloalkenyl, heterocyclyl, etc.; R5 = halo, CF3, S(O)0-2R14; R14 = H, CF3, (un)substituted alkyl; R8-10, R9a, R10a = independently H, (un)substituted alkyl, aryl; with provisos], their its enantiomers, diastereoisomers, tautomers, hydrates, solvates and pharmaceutically acceptable salts and to their use as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.  Thus, II was prepd. and evaluated for its FPRL-1 modulatory activity (EC50 = 4.6 nM).

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.

 View the full-text here.

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