July 15, 2013

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2013 ACS

Patent Number: WO 2013062947
Title: Preparation of amide derivatives of N-urea substituted amino acids and dipeptides as N-formyl peptide receptor like-1 (FPRL-1) modulators
Inventor(s): Beard, Richard L.; Duong, Tien T.; Donello, John E.; Viswanath, Veena; Garst, Michael E.
Patent Assignee(s): Allergan, Inc., USA
Source: PCT Int. Appl., 119pp. CODEN: PIXXD2
Language: English

Abstract:
The invention is related to the prepn. of novel amide derivs. of N-urea substituted amino acids I [X = (C:O)a; Y = (CR9aR10a)b; a = 1 and b = 0; a = 0 and b = 1; a = 1 and b = 1; R1 = (un)substituted alkyl, heterocyclyl, aryl, etc.; R2 = (un)substituted alkyl, aryl; R3-4, R6-7 = independently H, halo, NO2, (un)substituted cycloalkenyl, heterocyclyl, etc.; R5 = halo, CF3, S(O)0-2R14; R14 = H, CF3, (un)substituted alkyl; R8-10, R9a, R10a = independently H, (un)substituted alkyl, aryl; with provisos], their its enantiomers, diastereoisomers, tautomers, hydrates, solvates and pharmaceutically acceptable salts and to their use as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.  Thus, II was prepd. and evaluated for its FPRL-1 modulatory activity (EC50 = 4.6 nM).

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.

 View the full-text here.

Recent News

   
    June 30, 2014 | CHEMCATS on STN Enhanced with
    New Search and Display Fields and More Frequent
    Updates
    
    June 18, 2014
| SciFinder and ChemDraw Software
    Connection Now Available to Customers

    May 28, 2014 | CAS REGISTRY BLAST Upgrade
    Improves Search Capabilities and Results Ranking
   
                                                                     More News >> 

 Media Contact

 Name: Rhonda Ross
 Phone: 614-447-3624                                       
 Email: cas-pr@cas.org