July 8, 2013

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.


Patent Number: US8431717
Title: Process for the preparation of 5-(2-ethyl-dihydro-1h-inden-2-yl)-1h-imidazole and salts thereof
Inventor(s): Lusis, Viesturs; Muceniece, Dzintra; Reine, Inese; Zandersons, Armands
Patent Assignee(s): Grindeks JSC, Latvia
Source: PCT Int. Appl., 15 pp. CODEN: PIXXD2
Language: English

The invention provides an improved, highly efficient method for prepg. 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole (I), and its salts, in particular its pharmaceutically acceptable salts.  Compd. I·HCl was prepd. via formylation of 4-iodo-1-tritylimidazole; the resulting 1-tritylimidazole-4-carboxaldehyde underwent condensation with phthalide to give 2-(1-trityl-1H-imidazol-4-yl)indan-1,3-dione, which underwent ethylation to give 2-ethyl-2-(1-trityl-1H-imidazol-4-yl)indan-1,3-dione, which underwent hydrolysis to give 2-ethyl-2-(1H-imidazol-4-yl)indan-1,3-dione, which underwent redn. to give I·HCl.

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.

 View the full-text here.

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