June 9, 2014

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.


Patent Number: WO 2014055474
Title: Preparation of mannose derivatives for treating bacterial infections
Inventor(s): Bennani, Youssef Laafiret; Liu, Bingcan
Patent Assignee(s): Vertex Pharmaceuticals Incorporated, USA
Source: PCT Int. Appl., 81pp. CODEN: PIXXD2
Language: English

Disaccharides I, wherein ring A is a substituted sugar residue; each X is independently substituted amine, O, S; Y and Z are independently substituted amine, O, S; R' is absent, H, halogen, substituted O, substituted N, substituted S, alkyl, alkenyl, alkynyl, cycloalkyl; R is H, halogen, substituted O, substituted N, substituted S, alkyl, alkenyl, alkynyl, cycloalkyl; R and R' together form a cyclic ring or heterocyclic ring; R1 is alkyl, allkenyl, alkynyl, cycloalkyl, heterocyclyl, heteroaryl, were prepd. and used for the treatment or prevention of bacteria infections.  Thus, disaccharide II was prepd. and tested in vitro as antibacterial agent (Kd = 0.029 µM).

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.


 View the full-text here.

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