June 3, 2013

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2013 ACS

Patent Number: US 8404865
Title: Process for preparing azabicyclic compounds
Inventor(s): Ambhaikar, Narendra Bhalchandra; Bear, Brian Richard; Fanning, Lev T. D.; Hughes, Robert; Littler, Benjamin
Patent Assignee(s): Vertex Pharmaceuticals Incorporated, USA
Source: U.S. Pat. Appl. Publ., 8pp. CODEN: USXXCO
Language: English

Abstract:
The present invention relates to a process for prepg. azabicyclic compds. that are useful intermediates for synthesizing pharmaceutical compds. or salts thereof.  Thus, azabicyclo[2.2.1]heptane hydrochloride (I·HCl) was prepd. from trans-4-aminocyclohexanol via N-protection with Boc2O in CH2Cl2 contg. Et3N; mesylation with MsCl in CH2Cl2 contg. Et3N; N-deprotection with CF3CO2H; cyclization with aq. NaOH; and treatment with HCl gas.

 View the full-text here.

Recent News

    
    October 7, 2014 | CAS and Obiter Research form a
    multi-year collaboration to provide SciFinder to their
    research team
    
    September 29, 2014
| Cooperative Patent Classification
    (CPC) Combination Set Data Now Available in CAplus,
    INPADOCDB and USPAT Databases
         
    September 22, 2014
| STN Global Value Pricing
    Agreement Supports the Swedish Patent and
    Registration Office in Providing High Quality and
    Efficient Examination
    
 
                                                                     More News >> 

 Media Contact

 Name: Rhonda Ross
 Phone: 614-447-3624                                       
 Email: cas-pr@cas.org