June 3, 2013

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The following patent record is from the CAplusSM database.


Patent Number: US 8404865
Title: Process for preparing azabicyclic compounds
Inventor(s): Ambhaikar, Narendra Bhalchandra; Bear, Brian Richard; Fanning, Lev T. D.; Hughes, Robert; Littler, Benjamin
Patent Assignee(s): Vertex Pharmaceuticals Incorporated, USA
Source: U.S. Pat. Appl. Publ., 8pp. CODEN: USXXCO
Language: English

The present invention relates to a process for prepg. azabicyclic compds. that are useful intermediates for synthesizing pharmaceutical compds. or salts thereof.  Thus, azabicyclo[2.2.1]heptane hydrochloride (I·HCl) was prepd. from trans-4-aminocyclohexanol via N-protection with Boc2O in CH2Cl2 contg. Et3N; mesylation with MsCl in CH2Cl2 contg. Et3N; N-deprotection with CF3CO2H; cyclization with aq. NaOH; and treatment with HCl gas.

 View the full-text here.

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