June 3, 2013

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2013 ACS

Patent Number: US 8404865
Title: Process for preparing azabicyclic compounds
Inventor(s): Ambhaikar, Narendra Bhalchandra; Bear, Brian Richard; Fanning, Lev T. D.; Hughes, Robert; Littler, Benjamin
Patent Assignee(s): Vertex Pharmaceuticals Incorporated, USA
Source: U.S. Pat. Appl. Publ., 8pp. CODEN: USXXCO
Language: English

Abstract:
The present invention relates to a process for prepg. azabicyclic compds. that are useful intermediates for synthesizing pharmaceutical compds. or salts thereof.  Thus, azabicyclo[2.2.1]heptane hydrochloride (I·HCl) was prepd. from trans-4-aminocyclohexanol via N-protection with Boc2O in CH2Cl2 contg. Et3N; mesylation with MsCl in CH2Cl2 contg. Et3N; N-deprotection with CF3CO2H; cyclization with aq. NaOH; and treatment with HCl gas.

 View the full-text here.

Recent News

   
    August 4, 2014 | Chemical Abstracts Service (CAS)
    Strengthens Customer Support and Marketing with
    Representation in a New ACS International Office in
    Beijing

    
July 30, 2014 | CAS Announces the 2014 SciFinder
    Future Leaders in Chemistry
   
    July 28, 2014
| Latest Release of New STN Now
    Available, Expands Global Patent Coverage and
    Enhances Search Capabilities
      
                                                                     More News >> 

 Media Contact

 Name: Rhonda Ross
 Phone: 614-447-3624                                       
 Email: cas-pr@cas.org