June 3, 2013

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.


Patent Number: US 8404865
Title: Process for preparing azabicyclic compounds
Inventor(s): Ambhaikar, Narendra Bhalchandra; Bear, Brian Richard; Fanning, Lev T. D.; Hughes, Robert; Littler, Benjamin
Patent Assignee(s): Vertex Pharmaceuticals Incorporated, USA
Source: U.S. Pat. Appl. Publ., 8pp. CODEN: USXXCO
Language: English

The present invention relates to a process for prepg. azabicyclic compds. that are useful intermediates for synthesizing pharmaceutical compds. or salts thereof.  Thus, azabicyclo[2.2.1]heptane hydrochloride (I·HCl) was prepd. from trans-4-aminocyclohexanol via N-protection with Boc2O in CH2Cl2 contg. Et3N; mesylation with MsCl in CH2Cl2 contg. Et3N; N-deprotection with CF3CO2H; cyclization with aq. NaOH; and treatment with HCl gas.

 View the full-text here.

Recent News

    October 28, 2015 | CAS and Influential Research
    Leaders in Japan Share Common Business
    Challenges in Driving Economic Development
    through Scientific Research

    September 1, 2015 | BizInt Smart Charts and New
    STN Collaboration Extends and Optimizes Intellectual
    Property Search Workflow

    August 7, 2015 | CAS Announces the 2015 SciFinder
    Future Leaders in Chemistry and First-Ever Alumni

                                                                    More News >> 

Media Contact

 Name: Rhonda Ross
 Phone: 614-447-3624
 Email: cas-pr@cas.org